Zetasizer Pro

The Zetasizer Pro is a robust and versatile system for the measurement of particle and molecular size and electrophoretic mobility and zeta potential of nanoparticles. It enables size measurements to be performed up to three times quicker, compared to previous models, accelerating sample throughput and freeing up operator and system time for other tasks.

Even novice users will produce the highest-quality measurements, thanks to the intuitive interface and the deep learning empowered data quality advice system that highlights issues and provides advice on how to overcome them.


The Zetasizer Pro incorporates Non-Invasive Back Scatter (NIBS®) technology for the precise measurement of particle and molecular size over an extended concentration range.

The system also provides excellent zeta and electrophoretic mobility measurements using M3-PALS technology. The addition of Constant Current Mode for measuring electrophoretic mobility and zeta potential in high conductivity media reduces the likelihood of errors associated with charge screening at higher ion concentrations.

A wide choice of cuvettes is available for a variety of measurement applications, including disposable and affordable folded capillary cells to enable measurements in very low sample volumes using our patented diffusion barrier method, without direct sample-electrode contact.

The new software suite, ZS Xplorer, is designed to simplify and automate even complex analysis, allowing challenging measurements to be completed without expert knowledge. Its unique sample-centric workflow delivers the ultimate in usability and flexibility, meaning it’s now faster and easier than ever to get from sample input to result output.


  • NIBS optics for versatile, high sensitivity, particle and molecular size measurements
  • Dynamic Light Scattering (DLS) measures particle and molecule size, from 0.6 nm – 10 µm
  • M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements
  • ZS Xplorer software suite for simple and flexible method set-up and data analysis
  • Adaptive Correlation for faster, more reproducible sizing measurements with less sample preparation
  • Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
  • Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity.  Also includes polarization filters for DDLS measurements.

How it Works:

The Zetasizer Ultra incorporates two technologies in a single compact unit, with a range of options and accessories to optimize and simplify the measurement of different sample types.
The Zetasizer Pro incorporates two technologies in a single compact unit, with a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering (DLS) is used to measure particle and molecule size. DLS measures the diffusion of particles moving under Brownian motion and converts this to particle size and particle size distribution using the Stokes-Einstein relationship. Non-Invasive Back-Scatter (NIBS) technology is incorporated to give the highest sensitivity within the broadest range of sizes and concentrations.

DLS is a highly flexible sizing method which is rapid, accurate and repeatable. It requires only small volumes of sample for analysis, and is non-destructive. This technique is material-independent and therefore extremely widely applicable.

ZS Xplorer Software Suite
The software is designed to be very easy to use, even whilst enabling the rapid construction of complex methods. Information on the sample, its conditions, and the variables to be tested are entered at the beginning of a run, and ZS Xplorer uses this information intelligently to optimize the method for that sample. A deep learning empowered data quality guidance system provides feedback on results and offers clear advice on how data may be improved if required.

Electrophoretic Light Scattering (ELS) is used to measure zeta potential. An electric field is applied to a solution of molecules or a dispersion of particles which move with a velocity related to their charge. This velocity is measured using a patented laser interferometric technique called M3-PALS (Phase Analysis Light Scattering). This enables the calculation of electrophoretic mobility, and from this, the zeta potential and zeta potential distribution of a sample.

The use of ELS commonly relates to stability and formulation applications. Particles or molecules with no net charge may bind together, which may be a challenge in systems such as protein formulations which are prone to aggregation. Particles or molecules which have either a net positive or net negative charge will better maintain a distance from one another, creating a stable system. The formulation containing these particles or molecules is very influential on their charge state, and changes to formulation attributes such as pH, additive concentration and ionic concentration can impact product stability and shelf life.

The MPT-3 Auto titrator enables study of the effect of changes in pH.

A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume and concentration.


SV-10 Viscometer

The SV-10 measures viscosity with the accuracy required for dynamic light scattering for the conversion of… Read more

Disposable Folded Capillary Cell (DTS1070)

The zeta potential of colloids and molecules is extremely sensitive to contamination from… Read More

Universal 'dip' Cell Kit

The dip cell is used for the measurement of zeta potential of samples in… Read More

High concentration zeta potential cell kit

The high concentration cell enables the measurement of the zeta potential of samples with… Read More

12mm Glass cell (PCS1115)

Glass cuvette for use with the dip cell… Read More

12mm square glass cell (PCS8501)

Glass cuvette for batch measurements… Read More

Low-volume quartz batch cuvette (ZEN2112)

Low-volume quartz batch cuvette for size and molecular… Read More

12mm Square Polystyrene Cuvettes (DTS0012)

Disposable polystyrene cuvettes… Read More

Disposable Solvent Resistant Micro Cuvette (ZEN0040)

Disposable plastic micro cuvette, for size measurement at… Read More