Zetasizer Nano S

Performance with simplicity.

The Zetasizer Nano S is a research grade dynamic light scattering system for sub-micron particle and molecular size and molecular weight measurement that combines performance and versatility with exceptional ease of use. The system can be upgraded to add zeta potential capability at a later date.


The Zetasizer Nano S is the system of choice where the highest sensitivity and widest size range is required. It has the same sizing capability as the top of the range Zetasizer Nano ZS.

It is a particle size analyzer for the enhanced detection of aggregates, measurement of small or dilute samples, or samples at high concentration, plus a molecular weight analyzer for molecular size and molecular weight measurement.

Static light scattering measurements enable determination of the second virial coefficient for macromolecule solubility tests.


  • Size measurement from 0.3nm (diameter) to 10 microns using patented NIBS (Non-Invasive Back Scatter) technology.
  • The Expert advice report gives help to improve sample preparation or the measurement procedure.
  • Research software option gives access to further features and analysis algorithms for the light scattering specialist.
  • Alternative laser, 50mW at 532nm for samples incompatible with the standard 633nm laser fitted.
  • Molecular weight measurement down to 980Da.
  • Second virial coefficient measurement for solubility.
  • Automated temperature trend measurements.
  • Sample concentrations from 0.1ppm to 40%w/v.
  • Protein size measurement as dilute as 0.1mg/mL (Lysozyme).
  • A Quality Factor gives confidence in the data.
  • 21CFR part 11 software option enables compliance with ER/ES.
  • Automation of measurements using an autotitrator option.
  • Flow mode capability to enable use as a GPC / SEC detector.
  • Optical filter option to improve measurements with fluorescent sample.
  • Temperature range extension option to 120ºC.
  • Systems can be upgraded to add zeta potential at a later date.

How it Works:

The Zetasizer Nano S incorporates 2 techniques in a single compact unit, and has a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering is used to measure particle size and molecule size. This technique measures the diffusion of particles moving under Brownian motion, and converts this to size and a size distribution using the Stokes-Einstein relationship. Non-Invasive Back Scatter technology (NIBS) is incorporated to give the highest sensitivity simultaneously with the highest dynamic size and concentration range.

Static Light Scattering is used to determine the molecular weight of proteins and polymers. In this technique, the scattering intensity of a number of concentrations of the sample is measured, and used to construct a Debye plot. From this the average molecular weight and second virial coefficient can be calculated.
This measurement is very demanding on the sensitivity and stability of the whole system, and means that every element of the design has been optimised to ensure accuracy and repeatability

The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place to look for the success of a measurement, and expert advice is given to assist with data interpretation.

The MPT-2 Autotitrator enables the study the effect of changes in pH, conductivity, or any additive to be automated.
A range of disposable and reusable cells are available to optimise the measurement in terms of sample volume, concentration and for flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.



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