Author: Particulate Systems a Division of Micromeritics Instrument Corp

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Outlining Zeta Potential Measurements

Outlining Zeta Potential Measurements Zeta potential measurements are a common protocol when analyzing colloidal systems (beverages, food, inks, paints, pharmaceuticals, etc.). It is a complex parameter that defines the electro-kinetic potential of heterogeneous liquids, typically formulations comprising microscopic/nanoscale insoluble particles dispersed in a mobile phase. The sheer breadth of that definition indicates how complex zeta […]

Quality of Particle Sample Measurement

Quality of Particle Sample Measurement Quality in a particle characterization measurement can be defined using the term “accuracy”, which is composed of both bias and precision. Bias is a measure of how the measured value compares with the “true” value or commonly accepted value. This true value may be established through other (certified) reference measurement […]

Formulation Analysis: 4 Factors Affecting Stability

Formulation Analysis: 4 Factors Affecting Stability A formulation is loosely defined as the structured mix of ingredients in a finished product. Typical components include a continuous phase, a dispersed phase, stabilizing agents, and various additives which combine to perform a virtually limitless range of functions. However, the sheer versatility offered by formulation engineering is also […]

The Basic Statistical Numbers in Particle-Size Distribution Analysis

The Basic Statistical Numbers in Particle-Size Distribution Analysis Mean:The mean is an average over the entire distribution. There are different types of means that can be calculated from the same set of data. (See the next blog for more details of various means.) Median: The median is the value that divides the population into two […]

What is Electrical Sensing Zone Method (ESZ)?

What is Electrical Sensing Zone Method (ESZ)? It is a widely accepted technology in the field of medical technology that presently over 98% of automated cell counters incorporate the ESZ. This method can be used to count and size any particulate material that can be suspended in an electrolyte solution. In an ESZ experiment, a […]

How Dynamic Light Scattering (DLS) Works

How Dynamic Light Scattering (DLS) Works In dynamic light scattering, the speed at which the particles are diffusing due to Brownian motion is measured. This is done by measuring the rate at which the intensity of the scattered light fluctuates when detected using a suitable optical arrangement. How do these fluctuations in the intensity of […]

Characterization Of Pore Size Distribution Of Track-Etched Membranes

Characterization Of Pore Size Distribution Of Track-Etched Membranes BACKGROUND: Track-etched membranes are thin polymeric materials with a well-defined pore structure created by either irradiation with particles or ions of known size/or by chemical etching. These processes permit careful control of membrane pore size and density. Track-etched membranes are considered to have cylindrical pores (with diameters […]

Pharmaceutical Oral, Injectable and Semi-Solid Formulating

Pharmaceutical Oral, Injectable and Semi-Solid Formulating Pharmaceutical Formulating is the science of mixing different chemical components with a pharmaceutically active ingredient to achieve a final desired therapeutic action. The elements are often not fully compatible and must be mixed following a strict procedure to obtain a stable and durable structure. This task is even more […]